The Brown Alga Padina australis Total Extract and Depressive-like Behavior Following BCG Inoculation in Mice

Background: Depression is an important psychological disorder because it a common mental illness that leads to morbidity and suicide. Although appropriate antidepressant drugs exist, they usually have unpleasant side effects delayed onset. Objectives: Introducing new compounds such as medicinal plants oceanic living organisms alga appropriate. Here the depressive-like of Padina australis Hauck total extract (PAE) were evaluated following depression induced by Bacillus Calmette–Guérin (BCG) in mice. Methods: Male NMRI mice (average weight: 27±2 g) used. A single BCG 0.2 mL/mouse was inoculated. PAE effective dose (40 mg/kg) imipramine (10 administered reference drug for 14 days. The control animals received normal saline. All treatments intraperitoneally. After evaluating locomotor activity, different criteria assessed forced swimming test (FST), sucrose preference (SP) test, novelty-suppressed feeding (NSFT). Results: BCG. selected did not cause significant change activity compared with (139±16.9 count), while immobility time FST reduced (45.1±11.4 s vs BCG, P<0.001). During NSFT, latency decreased (94.7±18.5 P=0.0365), food intake increased (17.4±2.11 mg/g body weight P=0.023), SP up 79.3±4.7%. These changes similar imipramine. Conclusion: showed antidepressant-like despair behavior during FST. Based on stress declined, animal appetite increased, revealed remission anhedonia. Further studies are suggested regarding partitions.